Seikaly owns and runs a multi-million dollar real estate investment company; he is also an investor in the South Beach, Miami restaurants Quattro, Sosta, Solea, and Club Wall.
He is also an avid music lover, and has been producing and working as a house music DJ in some of the biggest clubs in the world and has singles released on Nervous Records, Subliminal Records and many more.
He has his own radio show on Sirius/XM Electric Area called SugarFree which airs every Saturday and Monday.
Every year, Seikaly hosts the annual Rony Seikaly Golf Tournament for cystic fibrosis.
When Magic Johnson returned to the NBA HIV-positive, and there was opposition to his inclusion in the league, because of his health status, Seikaly challenged him to a game of one-on-one to show everyone that HIV is not contagious by touch.
He was formerly married to Mexican model Elsa Benítez, the 2001 and 2006 cover girl for the Sports Illustrated swimsuit issues. They divorced in 2005; they have a daughter, Mila.