I’ve never blocked anyone. At least I’m pretty sure. There are, however, a couple people I generally scroll past. It works like a charm.
I have ignored some people on Facebook, though. It’s when it gets to a point that it fills up my feed and makes me resent them, like a kid from my mission who (among other things) got engaged and the wedding was like 4 months out and he posted a daily update of how many days left until he got married. Haven’t seen anything of his in like 8 years. Another is a girl who did nothing but continue to post wedding pictures every day a few years after the fact. And some various other reasons.