Once again, not knowing the man I couldn't say how much he knew or did not know about Loughner. I attempted to look it up, but all I could find were allegations that Dupnik knew that Loughner had past involvements with law enforcement. Even though Loughner had been making death threats, you would be surprised at how hard it is to get someone institutionalized. Sometimes the best that law enforcement can do is involuntarily commit someone to a local hospital until that hospital staff approves of their release into the community (which is usually a week, sometimes more, sometimes less), and that takes a type of "probable cause".
As for "unprofessional", I'm not going to fault the man for speaking his mind on what he feels is part of the problem. I didn't take from his quote that he was blaming radio personalities for the murders specifically, but that they, in a way, are part of the problem of the political mood in this country. Do you feel that the various radio personalities that I mentioned above are helping the situation?
Also, not sure if you live in the Tucson area or not, you may be informed on the Sheriff's political platform then I am. I, like most of the country, learned of him through this tragic event. However, I found truth in the aforementioned quote. Whether it comes from a caring civil servant or a transparently pandering politician, that doesn't mean it isn't true.