The positions of the world's major medical organizations range from considering neonatal circumcision as having a modest health benefit that outweighs small risks to viewing it as having no benefit and significant risks. No major medical organization recommends either universal circumcision for all infant males (aside from the recommendations of the World Health Organization for parts of Africa), or banning the procedure.[7] Ethical and legal questions regarding informed consent and autonomy have been raised over non-therapeutic neonatal circumcision.[8][9]
A 2009 Cochrane meta-analysis of studies done on sexually active men in Africa found that circumcision reduces the infection rate of HIV among heterosexual men by 38–66% over a period of 24 months.[10] The WHO recommends considering circumcision as part of a comprehensive HIV program in areas with high endemic rates of HIV, such as sub-Saharan Africa,[11][12] where studies have concluded it is cost-effective against HIV.[11] Circumcision reduces the incidence of HSV-2 infections by 28%,[13] and is associated with reduced oncogenic HPV prevalence[14] and a reduced risk of both UTIs and penile cancer,[5] but routine circumcision is not justified for the prevention of those conditions.[2][15] Studies of its protective effects against other sexually transmitted infections have been inconclusive. A 2010 review of literature worldwide found circumcisions performed by medical providers to have a median complication rate of 1.5% for newborns and 6% for older children, with few severe complications.[16] Bleeding, infection and the removal of either too much or too little foreskin are the most common complications cited.[16][17] Circumcision does not appear to have a negative impact on sexual function.[18]