Yes. It does. I would hire another 20 people, right now, if all I had was the salary. The matching funds/FICA, worker's comp, health .. it just makes employees way too expensive. I know that probably sounds harsh, but it's simply an economic reality.
If it weren't for the matching funds/FICA, etc. you'd probably have to put most of that cost into the employee's wages anyhow. I wouldn't work for 150% of my current salary if I had to pay for all of that (say, as an independent contractor).