Going back to my link about MiRNA, I've filled in/relearned a little. Red Blood Cells extrude their nucleus, mitochondria and Endoplasmic Reticulum early in development towards maturity. Scientists say this may be to reduce size constraints and enable RBC flow through very small capillaries. I think White Blood Cells also. I see some reports disputing this and asserting other possible functional "reasons" or factors. I question why macrophages can apparently circulate just fine everywhere.... Thus it is thought by
@One Brow that a vaccine that relies on patient cell machinery involved in producing an antigen from a mRNA carried into a patient cell by any mechanism whether viral or any other method for getting across the patient's cell membrane, would not be functional inside an RBC or platelet or white cell or lymphocyte where those known translational bodies must b e present.
I am assuming that any carrier capable of emplacing mRNA into a cell can do so in most cells. Whether this affects clotting generally would be a whole different discussion. Clotting is triggered by signals of cell or structural damage, where platelets are drawn by that signal and bind to stuff. If such an aggregation of blood cells detaches from a fixed site, you have a circulating clot that can cause a stroke or heart attack or impair circulation in the lungs. Whether an mRNA vaccine can cause such events is what scientists are discussing and fools like me are arguing about.
Let me clear. If this were a primary issue, we'd already know a helluva lot about it, thousands of vaccinated people would be dropping dead the very day of their vaccinations, and Bill Gates and other backers of the vaccines would be hiding all their assets in offshore accounts under fake names.
The question is already in the category of pathological conditions that can with some rare or long-term delayed rate of occurrence. Maybe only affecting people with specific pre-existing conditions or genetic factors.
Still worth studying.
But the article I cited is something else. Three scientists in Beijing showing RBC miRNA storage, and probably synthesis as well, as a significant force in human health in many ways, with literally hundreds of miRNA products with widely varying effects, some shown to be in large circulation in the body and derived from the red blood cells. No nuclear, mitochondrial or endoplasmic reticulum-based productions.
Could be produced by residual functional RNA or protein products from stem cell origin. I don't know. Maybe nobody knows yet. A good question.
Means mRNA carried into any blood cell could potentially be processed into an antigen. Without a nucleus, mitichondria, or ER.
We won't know how safe mRNA vaccines are unless we track a whole shipload of potential or imagined downstream effects, most of whose pathways we know little about even now.
We would do a lot better to produce and deploy a traditional vaccine. In the long term, we have issues with any kind of vaccine. Traditional vaccines have some kind of track record and various disputed problems. Statists reflexively deny questions and reports, and with pre-determined bias set out to dismiss complaints. Not a good policy for regulators, government agencies, or corporations, not really good public behavior for media or social sites or political parties or activist groups.
Hard job, no doubt, to keep scientific objectivity and unbiased work in view. Must be the goal..
