The Simpsons has been subject to diminishing returns for 10+ years, but occasionally whips out a throwback episode. They recently had one involving Millhouse shaving part of his head and standing on paint cans pretending to be an adult that had some particularly inspired moments.
Futurama will, I suspect, be a show that is an odd touchstone and remembered as far more important in the history of television that it probably actually is. The list of "science fiction comedies," as opposed to science fiction parodies, is actually very short but they develop very passionate fan bases. If nothing else, Zoidberg Halloween costumes always prove to be awesome so we should thank Futurama for that.