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A study yesterday in the New England Journal of Medicine from long-COVID researchers at Washington University School of Medicine in St. Louis shows the risk of long COVID has decreased over time, most likely due to the impact of vaccination.
"We had a hunch that things have changed during the pandemic after the initial couple years, which were brutal," said Ziyad Al-Aly, MD, senior author of the study, in an interview. "But a hunch is not data. This study now shows COVID is dynamic, and I was pleasantly surprised by how much vaccines made a dent in preventing long COVID."
In decomposition analyses, researchers found that 28.11% (95% CI, 25.57% to 30.50%) of the decrease in long COVID incidence was attributable to variant strain-related effects and that 71.89% (95% CI, 69.50% to 74.43%) was attributable to COVID-19 vaccines.
"The lion's share of the reduction is attributed to vaccination, with a 30% reduction to viral characteristics over time," said Al-Aly.